The Allen Lab has published over 65 research articles that utilize X-ray crystallography, with more than 145 protein structures deposited in the Protein Data Bank
Click here for a complete list of the lab's published work
Click here for a complete list of structures determined in the lab and deposited in the PDB
Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning. Ortet PC, Muellers SN, Viarengo-Baker LA, Streu K, Szymczyna BR, Beeler AB, Allen KN, Whitty A. J Am Chem Soc. 2021 Mar 17;143(10):3779-3793. doi: 10.1021/jacs.0c09799. Epub 2021 Mar 8. PMID: 33683866.
Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2. Tararina MA, Dam KK, Dhingra M, Janda KD, Palfey BA, Allen KN. Biochemistry. 2021 Feb 2;60(4):259-273. doi: 10.1021/acs.biochem.0c00855. Epub 2021 Jan 19. PMID: 33464876.
Glycoconjugate pathway connections revealed by sequence similarity network analysis of the monotopic phosphoglycosyl transferases. O'Toole KH, Imperiali B, Allen KN. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2018289118. doi: 10.1073/pnas.2018289118. PMID: 33472976; PMCID: PMC7848588.
Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions. Ji T, Zhang C, Zheng L, Dunaway-Mariano D, Allen KN. Biochemistry. 2018 Jun 26;57(25):3480-3492. doi: 10.1021/acs.biochem.8b00223. Epub 2018 May 11. PubMed PMID: 29695157.
Membrane association of monotopic phosphoglycosyl transferase underpins function. Ray LC, Das D, Entova S, Lukose V, Lynch AJ, Imperiali B, Allen KN. Nat Chem Biol. 2018 Jun;14(6):538-541. doi: 10.1038/s41589-018-0054-z. Epub 2018 May 16. PubMed PMID: 29769739; PubMed Central PMCID: PMC6202225.
Exploring the structural origins of cryptic sites on proteins. Beglov D, Hall DR, Wakefield AE, Luo L, Allen KN, Kozakov D, Whitty A, Vajda S. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3416-E3425. doi: 10.1073/pnas.1711490115. Epub 2018 Mar 26. PubMed PMID: 29581267; PubMed Central PMCID: PMC5899430.
Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A. Lin L, Olson ME, Sugane T, Turner LD, Tararina MA, Nielsen AL, Kurbanov EK, Pellett S, Johnson EA, Cohen SM, Allen KN, Janda KD. J Med Chem. 2020 Oct 8;63(19):11100-11120. doi: 10.1021/acs.jmedchem.0c01006. Epub 2020 Sep 18. PMID: 32886509; PMCID: PMC7581224.
Bioinformatic Analysis of the Flavin-Dependent Amine Oxidase Superfamily: Adaptations for Substrate Specificity and Catalytic Diversity. Tararina MA, Allen KN. J Mol Biol. 2020 May 1;432(10):3269-3288. doi: 10.1016/j.jmb.2020.03.007. Epub 2020 Mar 19. PubMed PMID: 32198115; PubMed Central PMCID: PMC7321841.
Lanthanide-Binding Tags for 3D X-ray Imaging of Proteins in Cells at Nanoscale Resolution. Victor TW, O'Toole KH, Easthon LM, Ge M, Smith RJ, Huang X, Yan H, Chu YS, Chen S, Gursoy D, Ralle M, Imperiali B, Allen KN, Miller LM. J Am Chem Soc. 2020 Feb 5;142(5):2145-2149. doi: 10.1021/jacs.9b11571. Epub 2020 Jan 21. PubMed PMID: 31923358.
Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase. Muellers SN, Nyitray MM, Reynarowych N, Saljanin E, Benzie AL, Schoenfeld AR, Stockman BJ, Allen KN. Biochemistry. 2022 Sep 6;61(17):1853-1861. doi: 10.1021/acs.biochem.2c00361. Epub 2022 Aug 22. PMID: 35994320; PMCID: PMC10845162.
MEnTaT: A machine-learning approach for the identification of mutations to increase protein stability. Muellers SN, Allen KN, Whitty A. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2309884120. doi: 10.1073/pnas.2309884120. Epub 2023 Dec 1. PMID: 38039271; PMCID: PMC10710055.
A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation. DiRusso CJ, DeMaria AM, Wong J, Wang W, Jordanides JJ, Whitty A, Allen KN, Gilmore TD. J Biol Chem. 2023 Dec;299(12):105396. doi: 10.1016/j.jbc.2023.105396. Epub 2023 Oct 27. PMID: 37890781; PMCID: PMC10694592.
Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble. Majumder A, Vuksanovic N, Ray LC, Bernstein HM, Allen KN, Imperiali B, Straub JE. J Biol Chem. 2023 Oct;299(10):105194. doi: 10.1016/j.jbc.2023.105194. Epub 2023 Aug 25. PMID: 37633332; PMCID: PMC10519829.
Co-conserved sequence motifs are predictive of substrate specificity in a family of monotopic phosphoglycosyl transferases. Anderson AJ, Dodge GJ, Allen KN, Imperiali B. Protein Sci. 2023 Jun;32(6):e4646. doi: 10.1002/pro.4646. PMID: 37096962; PMCID: PMC10186338.
Proteome-wide bioinformatic annotation and functional validation of the monotopic phosphoglycosyl transferase superfamily. Durand T, Dodge GJ, Siuda RP, Higinbotham HR, Arbour CA, Ghosh S, Allen KN, Imperiali B. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2417572121. doi: 10.1073/pnas.2417572121. Epub 2024 Nov 27. PMID: 39602253.
Dual Glycosyltransferases from Campylobacter concisus Diverge from the Canonical Campylobacter N-Linked Glycan Assembly Pathway. Arbour CA, Vuksanovic N, Allen KN, Imperiali B. Dual Biochemistry. 2024 Sep 17;63(18):2369-2379. doi: 10.1021/acs.biochem.4c00351. Epub 2024 Aug 28. PMID: 39192839.
Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA. Vuksanovic N, Clasman JR, Imperiali B, Allen KN. Protein Sci. 2024 Jan;33(1):e4848. doi: 10.1002/pro.4848. PMID: 38019455; PMCID: PMC10731488.